Pernicious anemia : when your body cannot absorb vitamin B12

Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract. Vitamin B12, in turn, is necessary for the formation of red blood cells. Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia.

Intrinsic factor is a protein the body uses to absorb vitamin B12. When gastric secretions do not have enough intrinsic factor, vitamin B12 is not adequately absorbed, resulting in pernicious anemia and other problems related to low levels of vitamin B12.

Because vitamin B12 is needed by nerve cells and blood cells for them to function properly, deficiency can cause a wide variety of symptoms, including fatigue, shortness of breath, tingling sensations, difficulty walking, and diarrhea.

Other causes of low levels of intrinsic factor (and thus of pernicious anemia) include atrophic gastric mucosa, autoimmunity against gastric parietal cells, and autoimmunity against intrinsic factor.

Absence of intrinsic factor itself is the most common cause of vitamin B12 malabsorption. Intrinsic factor is produced by cells within the stomach. In adults, the inability to make intrinsic factor can be the result of chronic gastritis or the result of surgery to remove the stomach. The onset of the disease is slow and may span decades.

Very rarely, infants and children are found to have been born lacking the ability to produce effective intrinsic factor. You need a defective gene from both parents to get it. However, most often, most forms of megaloblastic anemia in children results from other causes of vitamin B12 deficiency or other vitamin deficiencies.

Although a juvenile form of the disease can occur in children, pernicious anemia usually does not appear before the age of 30. The average age at diagnosis is 60 years. In fact, one recent study revealed that nearly 2 percent of individuals over 60 years old suffer from pernicious anemia. Furthermore, slightly more women than men are affected. The disease can affect all racial groups, but occurs more often among people of Scandinavian or Northern European descent.

Risk factors include a family history of pernicious anemia, Scandinavian or Northern European descent, and a history of autoimmune endocrine disorders. The disease is seen in association with some autoimmune endocrine diseases such as type 1 diabetes, hypoparathyroidism, Addison's disease, hypopituitarism, testicular dysfunction, Graves disease, chronic thyroiditis, myasthenia gravis, secondary amenorrhea and vitiligo.

In addition to pernicious anemia, other causes of vitamin B12 malabsorption include:

  • Nutrition (strict vegetarians without B12 supplementation, poor diet in infant, or poor maternal nutrition during pregnancy)
  • Infection (intestinal parasites, bacterial overgrowth)
  • Gastrointestinal disease (stomach removal surgery, celiac disease (sprue), Crohn's disease)
  • Drugs (colchicine, neomycin, tuberculosis treatment with para amino salicylic acid)
  • Metabolic disorders (methylmalonic aciduria, homocystinuria)

Symptoms of pernicious anemia

Many cells in our body need vitamin B12, including nerve cells and blood cells. Inadequate vitamin B12 gradually affects sensory and motor nerves, causing neurological problems to develop over time. It is important to know that the neurological effects of vitamin B12 deficiency may be seen before anemia is diagnosed.

The anemia also affects the gastrointestinal system and the cardiovascular system. The following symptoms may indicate pernicious anemia:

  • Shortness of breath
  • Fatigue
  • Pallor
  • Rapid heart rate
  • Loss of appetite
  • Diarrhea
  • Tingling and numbness of hands and feet
  • Sore mouth
  • Unsteady gait, especially in the dark
  • Tongue problems
  • Smell, impaired
  • Gums, bleeding
  • Positive Babinski's reflex
  • Loss of deep tendon reflexes
  • Personality changes, "megaloblastic madness"

Treatment of pernicious anemia

Monthly vitamin B12 injections are the definitive treatment to correct the vitamin B12 deficiency. This therapy corrects the anemia and may correct the neurological complications if given soon enough. Since about 1% of vitamin B12 is absorbed (even in the absence of intrinsic factor), some doctors recommend that elderly patients with gastric atrophy take oral vitamin B12 supplements in addition to monthly injections.

There is also a preparation of vitamin B12 that may be given intranasally (in the nose). A well-balanced diet is essential to provide other elements such as folic acid, iron, and vitamin C for healthy blood cell development.

Prevention of pernicious anemia

Pernicious anemia is not preventable, but with early detection and treatment of vitamin B12 deficiency, complications are readily controlled. Again, a well-balanced diet with appropriate nutritional supplements is a winning combination.

Appropriate nutritional supplements to avoid vitamin deficiency and pernicious anemia


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