Cymbalta side effects

Cymbalta side effects

Cymbalta side effects :
a look at Purpose, Interactions and Warnings

Cymbalta (Duloxetine) is indicated for the treatment of major depression and diabetic peripheral neuropathic pain. The drug may also be effective in urinary incontinence.

Cymbalta side effects and interactions

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly.

This medicine is not indicated for patients with prior hypersensitivity to duloxetine, use MAO inhibitors or suffer from uncontrolled narrow-angle glaucoma.

There are alternatives to enduring the side effects of Cymbalta.
More information here.

Patients with the following conditions should be cautious and discuss with their doctor the interactions and side effects of cymbalta :

  • Hepatic function impairment (administration not recommended; duloxetine is extensively metabolized in the liver)
  • Concomitant use of serotonergic agents (eg, sertraline, venlafaxine, paroxetine) (risk of serotonin syndrome)
  • Concomitant use of CNS depressants (potential for exacerbation of psychomotor impairment)
  • Renal impairment (not recommended in end stage renal disease; potential for accumulation of active duloxetine metabolites)
  • Controlled narrow-angle glaucoma
  • History of seizures
  • Activation of mania/hypomania
  • Suicidal ideation and behavior or worsening depression
  • Sustained increases in blood pressure associated with duloxetine
  • Discontinuation symptoms, especially with abrupt withdrawal; gradual reduction is recommended

Observed Cymbalta side effects

Along with its needed effects, there may be unwanted Cymbalta side effects. Although not all of these Cymbalta side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur:


Anemia, leukopenia, increased white blood cell count, lymphadenopathy, and thrombocytopenia have occurred, albeit infrequently, with use of duloxetine (Prod Info Cymbalta(R), 2004).


A placebo-controlled trial with daily doses of 40 to 120 milligrams (mg) for 8 weeks caused a mean blood pressure increase of 2 millimeters of mercury (mm Hg) systolic and 0.5 mm Hg diastolic (Prod Info Cymbalta(R), 2004).

In a large cohort study including 481,744 persons and 1487 cases of SUDDEN CARDIAC DEATH occurring in a community setting, the use of selective serotonin reuptake inhibitors was not associated with an increased risk of sudden cardiac death (rate ratio, 0.95; 95% CI, 0.42 to 2.15). In contrast, users of tricyclic antidepressants in doses of 100 mg or higher (amitriptyline or its equivalent) had a 41% increased rate of sudden cardiac death (rate ratio, 1.41; 95% CI, 1.02 to 1.95) (Ray et al, 2004).

Small increases in systolic/diastolic blood pressure and decreases in heart rate compared to placebo have been observed with twice-daily dosing in recumbent healthy subjects; no significant Cymbalta side effects on blood pressure or heart rate were seen in the standing position (Sharma et al, 2000).


Patients treated with duloxetine for 9 weeks in clinical trials showed an average WEIGHT LOSS of 0.5 kilogram (kg), while placebo-treated patients showed a weight gain of 0.2 kg (Prod Info Cymbalto(R), 2004).


NAUSEA (up to 20% of patients), DIARRHEA (8%) or CONSTIPATION (11%), and DRY MOUTH (15%) have been relatively common adverse effects in the treatment of depression in open studies; less frequently, ANOREXIA and TASTE CHANGES have been described (Johnson et al, 1995; Berk et al, 1997; Ishigooka et al, 1996; Goodnick, 1999). In the absence of control groups, the true incidence of these effects is unknown.


Urinary hesitation may be attributable to duloxetine treatment (Prod Info Cymbalta(R), 2004). DYSURIA was reported in some depressed patients during therapy in an open study (Ishigooka et al, 1995). Causality is uncertain.


Duloxetine caused more sexual dysfunction in males, such as ejaculatory dysfunction, decreased libido, erectile dysfunction, delayed ejaculation, and particularly the ability to reach orgasm, than did placebo. Female sexual function was not affected by duloxetine (Prod Info Cymbalta(R), 2004).


Blurred vision was reported in 4% of patients treated with duloxetine (Prod Info Cymbalta(R), 2004).


Increased sweating (6%) has been reported with duloxetine treatment (Prod Info Cymbalta(R), 2004). Night sweats, pruritus, and rash have occurred with high frequency with duloxetine treatment. Acne, alopecia, cold sweat, ecchymosis, eczema, erythema, face edema, increased tendency to bruise, and photosensitivity reaction have been reported with lower frequency (Prod Info Cymbalta(R), 2004).


Small increases in heart rate and sleep disturbances (insomnia, abnormal dreams) have occurred following abrupt discontinuation of multiple-dose administration in healthy subjects (Sharma et al, 2000). However, doses in this study were relatively high (20 to 40 mg twice daily). Withdrawal data following once-daily doses of 20 mg in healthy subjects or depressed patients are unavailable.


Check with your doctor before taking Cymbalta while pregnant.

Other Cymbalta side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

There are alternatives to enduring Cymbalta side effects.
More information here.


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